JEAN SILVA
RNA & microRNA Lab

Ambiente 04 · RNA & microRNA Lab

MicroRNAs e doenças

Escolha uma doença e veja quais microRNAs os cientistas estudam nela — e o quanto já se sabe de fato.

MicroRNAsGenes / proteínasViasDoençaLeucemia linfocítica …miR-15a/miR-16-1BCL2let-7a-5pKRASApoptose intrínseca (…Sinalização RAS
  • Associação observacional
  • Evidência funcional experimental
  • Causalidade em modelo in vivo
  • Investigação clínica (não estabelecida)

Explicação

Selecione um nó da rede para abrir sua explicação.

1 · Fisiopatologia
Células passam a se multiplicar sem controle ou deixam de morrer quando deveriam.
2–4 · MicroRNAs, alterações e alvos

miR-15a/miR-16-1 · expressão reduzida · alvo BCL2

let-7a-5p · expressão reduzida · alvo KRAS

5 · Vias de sinalização
Apoptose intrínseca (BCL2) · Sinalização RAS
6 · Estudos

Calin et al., PNAS 2002

Cimmino et al., PNAS 2005

Takamizawa et al., Cancer Research 2004

Johnson et al., Cell 2005

7 · Limitações e conflitos
Associações prognósticas vêm de coortes específicas; nem toda LLC apresenta deleção 13q14.
8 · Potencial
Potencial prognóstico investigado; não são biomarcadores clínicos estabelecidos.

Nenhum microRNA apresentado aqui é biomarcador clínico estabelecido. Conteúdo educativo; não substitui avaliação médica.

Referências

  1. van Rooij E et al. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science, 2007.
  2. Thum T et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature, 2008.
  3. Patrick DM et al. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. Journal of Clinical Investigation, 2010.
  4. Hébert SS et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression. PNAS, 2008.
  5. Wang WX et al. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor protein-cleaving enzyme 1. Journal of Neuroscience, 2008.
  6. Poy MN et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature, 2004.
  7. Esau C et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metabolism, 2006.
  8. Kato M et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-β-induced collagen expression via inhibition of E-box repressors. PNAS, 2007.
  9. Krupa A et al. Loss of microRNA-192 promotes fibrogenesis in diabetic nephropathy. Journal of the American Society of Nephrology, 2010.
  10. Chau BN et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Science Translational Medicine, 2012.
  11. Cushing L et al. miR-29 is a major regulator of genes associated with pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology, 2011.
  12. Calin GA et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. PNAS, 2002.
  13. Cimmino A et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. PNAS, 2005.
  14. Takamizawa J et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Research, 2004.
  15. Johnson SM et al. RAS is regulated by the let-7 microRNA family. Cell, 2005.