Ambiente 04 · RNA & microRNA Lab
MicroRNAs e doenças
Escolha uma doença e veja quais microRNAs os cientistas estudam nela — e o quanto já se sabe de fato.
- Associação observacional
- Evidência funcional experimental
- Causalidade em modelo in vivo
- Investigação clínica (não estabelecida)
Explicação
Selecione um nó da rede para abrir sua explicação.
- 1 · Fisiopatologia
- O tecido do pulmão cicatriza em excesso e fica rígido, dificultando a respiração.
- 2–4 · MicroRNAs, alterações e alvos
miR-29 · expressão reduzida · alvo COL1A1 e genes de matriz
- 5 · Vias de sinalização
- TGF-β · Deposição de matriz extracelular
- 6 · Estudos
Cushing et al., American Journal of Respiratory Cell and Molecular Biology 2011
- 7 · Limitações e conflitos
- Parte dos dados vem do modelo de bleomicina em camundongo, que não reproduz toda a doença humana.
- 8 · Potencial
- Alvo terapêutico investigacional (miméticos de miR-29); sem uso clínico estabelecido.
Nenhum microRNA apresentado aqui é biomarcador clínico estabelecido. Conteúdo educativo; não substitui avaliação médica.
Referências
- van Rooij E et al. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science, 2007.
- Thum T et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature, 2008.
- Patrick DM et al. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. Journal of Clinical Investigation, 2010.
- Hébert SS et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression. PNAS, 2008.
- Wang WX et al. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor protein-cleaving enzyme 1. Journal of Neuroscience, 2008.
- Poy MN et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature, 2004.
- Esau C et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metabolism, 2006.
- Kato M et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-β-induced collagen expression via inhibition of E-box repressors. PNAS, 2007.
- Krupa A et al. Loss of microRNA-192 promotes fibrogenesis in diabetic nephropathy. Journal of the American Society of Nephrology, 2010.
- Chau BN et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Science Translational Medicine, 2012.
- Cushing L et al. miR-29 is a major regulator of genes associated with pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology, 2011.
- Calin GA et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. PNAS, 2002.
- Cimmino A et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. PNAS, 2005.
- Takamizawa J et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Research, 2004.
- Johnson SM et al. RAS is regulated by the let-7 microRNA family. Cell, 2005.