JEAN SILVA
RNA & microRNA Lab

Ambiente 03 · RNA & microRNA Lab

Atlas anatômico humano

Escolha um órgão do corpo e aproxime-se, passo a passo, até as moléculas que ajudam a controlá-lo.

Cérebro

Esquema 2D ilustrativo — não é modelo anatômico. A navegação 3D em 360° depende de modelos licenciados ainda não integrados.

Cérebro · MicroRNA

  • miR-124 — Muito abundante em neurônios.
    miR-124 também em:Epigenética
  • miR-134 — Localizado em dendritos de neurônios.
  • miR-29 — Família a/b/c; matriz extracelular e metilação.
    miR-29 também em:DoençasSimuladorEpigenética
  • miR-107 — Expressão reduzida em fases iniciais da doença de Alzheimer.
    miR-107 também em:Doenças
Doenças associadas:Doença de Alzheimer

Referências

  1. Zhao Y, Samal E, Srivastava D. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature, 2005.
  2. van Rooij E et al. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science, 2007.
  3. Thum T et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature, 2008.
  4. Makeyev EV et al. The microRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Molecular Cell, 2007.
  5. Schratt GM et al. A brain-specific microRNA regulates dendritic spine development. Nature, 2006.
  6. Hébert SS et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression. PNAS, 2008.
  7. Wang WX et al. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor protein-cleaving enzyme 1. Journal of Neuroscience, 2008.
  8. Johnson SM et al. RAS is regulated by the let-7 microRNA family. Cell, 2005.
  9. Cushing L et al. miR-29 is a major regulator of genes associated with pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology, 2011.
  10. Jopling CL et al. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science, 2005.
  11. Kato M et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-β-induced collagen expression via inhibition of E-box repressors. PNAS, 2007.
  12. Chau BN et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Science Translational Medicine, 2012.
  13. Chen JF et al. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nature Genetics, 2006.